Ceftriaxone-induced Agranulocytosis

Couto, Lénio and Goulart, André and Valadão, Ivone and Garça, Magda and Santos, Maria Beatriz and Cota, Pedro and Teixeira, Carolina (2021) Ceftriaxone-induced Agranulocytosis. European Journal of Case Reports in Internal Medicine, 8 (1). pp. 1-3. ISSN ISSN: 2284-2594

2215-Article Text-19493-1-10-20210106.pdf - Published Version

Download (257kB) | Preview
Official URL: https://www.ejcrim.com/index.php/EJCRIM/issue/view...


Ceftriaxone is a widely used antibiotic regarded as safe and effective. Drug-induced agranulocytosis is a life-threatening adverse reaction and few reports related to ceftriaxone were found in a review of the literature. The authors present a case of ceftriaxone-induced agranulocytosis, in which a brain abscess was diagnosed and ceftriaxone was commenced. Neutropenic fever occurred on the 29th day of therapy with a cumulative dose of 116 g ceftriaxone and a neutrophil nadir of 0.1×109/l. Ceftriaxone was withheld, filgrastim was administered for 3 days and neutrophil normalization was achieved. Although rare, ceftriaxone-induced agranulocytosis may occur in patients on a long course of ceftriaxone therapy. Prompt recognition and drug withdrawal are required.

Item Type: Article
Uncontrolled Keywords: Ceftriaxone, neutropenia, drug-induced agranulocytosis
Subjects: 600 Tecnologia - Scienze applicate
600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Marina Spanti
Date Deposited: 20 Dec 2021 15:08
Last Modified: 20 Dec 2021 15:08
URI: http://eprints.bice.rm.cnr.it/id/eprint/21170

Actions (login required)

View Item View Item