Couto, Lénio and Goulart, André and Valadão, Ivone and Garça, Magda and Santos, Maria Beatriz and Cota, Pedro and Teixeira, Carolina (2021) Ceftriaxone-induced Agranulocytosis. European Journal of Case Reports in Internal Medicine, 8 (1). pp. 1-3. ISSN ISSN: 2284-2594
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Abstract
Ceftriaxone is a widely used antibiotic regarded as safe and effective. Drug-induced agranulocytosis is a life-threatening adverse reaction and few reports related to ceftriaxone were found in a review of the literature. The authors present a case of ceftriaxone-induced agranulocytosis, in which a brain abscess was diagnosed and ceftriaxone was commenced. Neutropenic fever occurred on the 29th day of therapy with a cumulative dose of 116 g ceftriaxone and a neutrophil nadir of 0.1×109/l. Ceftriaxone was withheld, filgrastim was administered for 3 days and neutrophil normalization was achieved. Although rare, ceftriaxone-induced agranulocytosis may occur in patients on a long course of ceftriaxone therapy. Prompt recognition and drug withdrawal are required.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Ceftriaxone, neutropenia, drug-induced agranulocytosis |
| Subjects: | 600 Tecnologia - Scienze applicate 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 20 Dec 2021 15:08 |
| Last Modified: | 20 Dec 2021 15:08 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21170 |
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