The pleiotropic actions of vitamin D

Isaia, Giancarlo and Di Stefano, Marco and Bergui, Simona (2006) The pleiotropic actions of vitamin D. Clinical cases in mineral and bone metabolism, 3 (1). pp. 35-42. ISSN 1971-3266

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Abstract

General knowledge of the role of vitamin D3 in human physiology has been shaped by its discovery as a preventive agent of nutritional rickets, a defect in bone development due to inadequate uptake of dietary calcium. Studies on the function of the biologically active vitamin D3, 1,25-dihydroxyvitamin D3, have been greatly accelerated by the molecular cloning and structural analysis of the vitamin D3 receptor, which is a ligand-activated regulator of gene transcription. Molecular genetic techniques including genomics have helped to reveal that 1,25-dihydroxyvitamin D3 can control more than calcium homeostasis. It has effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Moreover, accumulating epidemiological and molecular evidence suggests that 1,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of breast, prostate and colon.

Item Type:	Article
Uncontrolled Keywords:	Vitamin D, pleiotropic actions, bone
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 612 Fisiologia umana > 612.7 Sistema muscoloscheletrico, tegumento
Depositing User:	Danilo Dezzi
Date Deposited:	24 Jan 2014 12:31
Last Modified:	24 Jan 2014 12:31
URI:	http://eprints.bice.rm.cnr.it/id/eprint/4681

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