Hormone replacement therapy and mild cognitive impairment in postmenopause

De Franciscis, Pietro and Luisi, A. and Matteo, M. and Basso, Antonio and Cerreto, V. and Cicatiello, R. and Marcello, A. and Muscio, M.F. and Vaccarella, L. and Labriola, Domenico and Colacurci, Nicola (2013) Hormone replacement therapy and mild cognitive impairment in postmenopause. Giornale italiano di ostetricia e ginecologia, 35 (3). pp. 457-461. ISSN 1971-1433

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Abstract

The mild cognitive impairment (MCI) is an impairment of cognitive abilities that not yet satisfies diagnostic criteria of dementia. Impaired cardiovascular parameters are associated with the risk of cognitive disorders. Low estrogen levels in postmenopause are related to impaired ability of the central nervous system and could explain the high incidence of cognitive disorders in postmenopausal women. The aim of this study was to assess cognitive performances in postmenopausal women affected by MCI and the impact of an HRT combination of low-dose oestradiol plus drospirenone. The evaluation of cognitive skills performed with neuropsychological tests showed that women on HRT had higher cognitive performances than controls, in particular they showed higher rates of short and long term memory, attention, verbal fluency and visuospatial performance. These ability are typically involved in the MCI. The beneficial effects of drospirenone on cardiovascular parameters could explain the reduce risk of developing dementia.

Item Type:	Article
Uncontrolled Keywords:	Mild cognitive impairment, menopause, drospirenone
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 618 Altri rami della medicina; Ginecologia e ostetricia, Pediatria, Geriatria
Depositing User:	Matteo Viola
Date Deposited:	11 Sep 2013 16:22
Last Modified:	11 Sep 2013 16:22
URI:	http://eprints.bice.rm.cnr.it/id/eprint/6792

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