The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; a dream for tendon repair?

Tetta, Ciro and Consiglio, Anna Lange and Bruno, Stefania and Tetta, Emanuele and Gatti, Emanuele and Dobreva, Miryana and Cremonesi, Fausto and Camussi, Giovanni (2012) The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; a dream for tendon repair? M.L.T.J. Muscles, Ligaments and Tendons Journal, 2 (3). pp. 212-221. ISSN 2240-4554

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Abstract

Tendon injuries represent even today a challenge as repair may be exceedingly slow and incomplete. Regenerative medicine and stem cell technology have shown to be of great promise. Here, we will review the current knowledge on the mechanisms of the regenerative potential of mesenchymal stem cells (MSCs) obtained from different sources (bone marrow, fat, cord blood, placenta). More specifically, we will devote attention to the current use of MSCs that have been used experimentally and in limited numbers of clinical cases for the surgical treatment of subchondral-bone cysts, bone-fracture repair and cartilage repair. Based on the recently emerging role in regenerative mechanisms of soluble factors and of extracellular vesicles, we will discuss the potential of non-cellular therapies in horse tendon injuries

Item Type:	Article
Uncontrolled Keywords:	Horse tendinopathies, microvesicles, regenerative medicine
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	16 Apr 2014 16:27
Last Modified:	16 Apr 2014 16:27
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8145

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