Ultrastructural features of skeletal muscle in adult and aging Ts65Dn mice, a murine model of Down syndrome

Cisterna, Barbara and Costanzo, Manuela and Scherini, Elda and Zancanaro, Carlo and Malatesta, Manuela (2013) Ultrastructural features of skeletal muscle in adult and aging Ts65Dn mice, a murine model of Down syndrome. M.L.T.J. Muscles, Ligaments and Tendons Journal, 3 (4). pp. 287-294. ISSN 2240-4554

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Abstract

Patients with Down syndrome (DS) suffer from muscle hypotonia and an altered motor coordination whose basic mechanisms are still largely unknown. Interestingly, they show muscle weakness like healthy aged subjects, suggesting possible similarity with sarcopenia: to test this hypothesis, the Ts65Dn mouse, a suitable animal model of DS, was employed. The fine structure of skeletal fibres of the quadriceps femoris muscle was analysed in adult (12 months) and aging (19 months) animals and their age-matched euploid controls by combining morphometry and immunocytochemistry at transmission electron microscopy. Results demonstrated structural alterations of mitochondria and myonuclei reminiscent of those observed in age-related sarcopenia, supporting the hypothesis that trisomy leads to an early aging of skeletal muscle consistent with the multi-systemic premature aging typical of DS

Item Type:	Article
Uncontrolled Keywords:	Aging, cell nucleus, Down syndrome, mitochondria, skeletal muscle, Ts65Dn mouse
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	14 Nov 2014 16:57
Last Modified:	14 Nov 2014 16:57
URI:	http://eprints.bice.rm.cnr.it/id/eprint/10097

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