Ferreira, Joaquim J. and Bhidayasiri, Roongroj and Colosimo, Carlo and Marti, Maria Jose and Zakine, Benjamin and Maisonobe, Pascal (2012) Survey of practices employed by neurologists for the definition and management of secondary non-response to botulinum toxin in cervical dystonia. Functional Neurology, 27 (4). pp. 225-230. ISSN 1971-3274
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Abstract
Secondary non-response (SNR) to botulinum toxin (BoNT) in cervical dystonia (CD) lacks a universal definition. We conducted a retrospective survey to develop a definition based on clinicians’ practice. Fifty-seven neurologists completed a 17-item questionnaire. In defining SNR, insufficiently improved posture was considered to be more relevant (98% of physicians) than insufficiently improved pain (86%). The most frequently used diagnostic test for SNR was the frontalis test (68%); antibody testing was performed by only 13% of physicians. Three consecutive unsuccessful injection cycles were considered the most appropriate indicator of SNR (55% of physicians). Physicians reported that 5.9% (median) of patients treated in 2008 became secondary non-responders to BoNT-A. The most common strategy for SNR was optimization of physiotherapy, considered by 98% of the physicians. On the basis of our findings, SNR can be defined as insufficiently improved posture after ≥3 unsuccessful injection cycles in CD patients previously achieving satisfactory results.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | botulinum toxin, cervical dystonia, non-response |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 08 Jan 2016 12:00 |
| Last Modified: | 08 Jan 2016 12:00 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/10758 |
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