Samson, Rebecca S. and Kolappan, Madhan and Thomas, David L. and Symms, Mark R. and Connick, Peter and Miller, David H. and Wheeler-Kingshott, Claudia A.M. (2013) Development of a high-resolution fat and CSF-suppressed optic nerve DTI protocol at 3T: application in multiple sclerosis. Functional Neurology, 28 (2). pp. 93-100. ISSN 1971-3274
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Abstract
Clinical trials of neuroprotective interventions in multiple sclerosis require outcome measures that reflect the disease pathology. Measures of neuroaxonal integrity in the anterior visual pathways are of particular interest in this context, however imaging of the optic nerve is technically challenging. We therefore developed a 3T optic nerve diffusion tensor imaging protocol incorporating fat and cerebrospinal fluid suppression and without parallel imaging. The sequence used a scheme with six diffusion-weighted directions, b=600smm-2 plus one b≈0 (b0) and 40 repetitions, averaged offline, giving an overall scan time of 30 minutes. A coronal oblique orientation was used with voxel size 1.17mmx1.17mmx4mm, We validated the sequence in 10 MS patients with a history of optic neuritis and 11 healthy controls: mean fractional anisotropy was reduced in the patients: 0.346(±0.159) versus 0.528(±0.123), p<0.001; radial diffusivity was increased: 0.940(±0.370)x10-6mm2s-1 compared to 0.670(± 0.221)x10-6mm 2s-1 (p<0.01). No significant differences were seen for mean diffusivity or mean axial diffusivity.
| Item Type: | Article |
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| Uncontrolled Keywords: | 3T, diffusion, multiple sclerosis, optic nerve, optic neuritis |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 17 Dec 2015 14:44 |
| Last Modified: | 17 Dec 2015 14:44 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/10833 |
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