Clerici, Angelo Maurizio and Bono, Giorgio and Delodovici, Maria Luisa and Azan, Gaetano and Cafasso, Giuseppina and Micieli, Giuseppe (2013) A rare association of early-onset inclusion body myositis, rheumatoid arthritis and autoimmune thyroiditis: a case report and literature review. Functional Neurology, 28 (2). pp. 127-132. ISSN 1971-3274
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Abstract
Sporadic inclusion body myositis (sIBM) is a slowly progressive, red-rimmed vacuolar myopathy leading to muscular atrophy and progressive weakness; it predominantly affects males older than fifty years, and is resistant to immunotherapy. It has been described in association with immuno-mediated thrombocytopenic purpura, multiple sclerosis, connective tissue disorders and, occasionally, rheumatoid arthritis. A 37-year-old man with longstanding rheumatoid arthritis and autoimmune thyroiditis with hypothyroidism was referred to us with slowly progressive, diffuse muscle weakness and wasting, which had initially involved the volar finger flexors, and subsequently also the ankle dorsiflexors and knee extensors. Needle electromyography showed typical myopathic motor unit potentials, fibrillation and positive sharp waves with normal nerve conduction studies. Quadriceps muscle biopsy was suggestive of sIBM. Considering data published in the literature, this case may be classified as an early-onset form. The patient was treated with long-term intravenous immunoglobulin and obtained a substantial stabilization of his muscle strength.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | autoimmune thyroiditis, connective tissue disorders, inclusion body myositis, inflammatory myopathy, rheumatoid arthritis |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 17 Dec 2015 14:09 |
| Last Modified: | 17 Dec 2015 14:09 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/10856 |
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