Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study

Thonnard, Marie and Gosseries, Olivia and Demertzi, Athena and Lugo, Zulay and Vanhaudenhuyse, Audrey and Bruno, Marie-Aurélie and Chatelle, Camille and Thibaut, Aurore and Charland-Verville, Vanessa and Habbal, Dina and Schnakers, Caroline and Laureys, Steven (2013) Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study. Functional Neurology, 28 (4). pp. 259-264. ISSN 1971-3274

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Abstract

Zolpidem has been reported as an “awakening drug” in some patients with disorders of consciousness (DOC). We here present the results of a prospective open-label study in chronic DOC patients. Sixty patients (35±15 years; 18 females; mean time since insult ± SD: 4±5.5 years; 31 with traumatic etiology) with a diagnosis of vegetative state/unresponsive wakefulness syndrome (n=28) or minimally conscious state (n=32) were behaviorally assessed using the Coma Recovery Scale-Revised (CRS-R) before and one hour after administration of 10 mg of zolpidem. At the group level, the diagnosis did not change after intake of zolpidem (p=0.10) and CRS-R total scores decreased (p=0.01). Twelve patients (20%) showed improved behaviors and/or CRS-R total scores after zolpidem administration but in only one patient was the diagnosis after zolpidem intake found to show a significant improvement (functional object use), which suggested a change of diagnosis. However, in this patient, a double-blind placebo-controlled trial was performed in order to better specify the effects of zolpidem, but the patient, on this trial, failed to show any clinical improvements. The present open-label study therefore failed to show any clinically significant improvement (i.e., change of Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study diagnosis) in any of the 60 studied chronic DOC patients.

Item Type: Article
Uncontrolled Keywords: disorders of consciousness, minimally conscious state, treatment, vegetative state, zolpidem
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
Depositing User: Marina Spanti
Date Deposited: 17 Dec 2015 13:05
Last Modified: 17 Dec 2015 13:05
URI: http://eprints.bice.rm.cnr.it/id/eprint/10929

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