Vlasveld, Imro and Aken, Maarten O. Van and Nieuwkoop, Cees Van (2014) Iatrogenic Cushing’s syndrome and Secondary Adrenal Insufficiency in an HIV Patientreceiving Fluticasone and Ritonavir. European Journal of Case Reports in Internal Medicine, 1 (1). pp. 1-4. ISSN 2284-2594
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Abstract
Objectives: To illustrate that the protease inhibitor (PI) ritonavir, widely used as part of the treatment for HIV, might cause drug–drug interactions with inhaled corticosteroids. Material and methods: A case report is presented. Results: An HIV-positive patient presented with gradually changing body composition that was ascribed to lipodystrophy. Finally, iatrogenic Cushing's syndrome with secondary adrenal insufficiency was diagnosed due to a drug–drug interaction of ritonavir and fluticasone. Conclusion: Lipodystrophy might mimic Cushing's syndrome. The combination of ritonavir and inhaled fluticasone may lead to systemic steroid excess causing Cushing's syndrome and secondary adrenal insufficiency.
| Item Type: | Article |
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| Uncontrolled Keywords: | Cushing's syndrome, secondary adrenal insufficiency, ritonavir |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.9 Altre malattie (altri rami della Medicina) > 616.91 Malattie da virus |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 07 Sep 2016 15:47 |
| Last Modified: | 07 Sep 2016 15:47 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/14977 |
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