Romano, Adele and Coccurello, Roberto and Giacovazzo, Giacomo and Bedse, Gaurav and Moles, Anna and Gaetani, Silvana (2014) Oleoylethanolamide: A Novel Potential Pharmacological Alternative to Cannabinoid Antagonists for the Control of Appetite. BioMed Research International, 2014. pp. 1-10. ISSN 2314-6133
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Oleoylethanolamide_A Novel Potential Pharmacological Alternative to Cannabinoid Antagonists for the Control of Appetite.pdf - Published Version Download (1MB) | Preview |
Abstract
The initial pharmaceutical interest for the endocannabinoid system as a target for antiobesity therapies has been restricted by the severe adverse effects of the CB1 antagonist rimonabant. This study points at oleoylethanolamide (OEA), a monounsaturated analogue, and functional antagonist of anandamide, as a potential and safer antiobesity alternative to CB1 antagonism. Mice treated with equal doses (5 or 10 mg/kg, i.p.) of OEA or rimonabant were analyzed for the progressive expression of spontaneous behaviors (eating, grooming, rearing, locomotion, and resting) occurring during the development of satiety, according to the paradigm called behavioral satiety sequence (BSS). Both drugs reduced food (wet mash) intake to a similar extent. OEA treatment decreased eating activity within the first 30 min and caused a temporary increase of resting time that was not accompanied by any decline of horizontal, vertical and total motor activity. Besides decreasing eating activity, rimonabant caused a marked increase of the time spent grooming and decreased horizontal motor activity, alterations that might be indicative of aversive nonmotivational effects on feeding. These results support the idea that OEA suppresses appetite by stimulating satiety and that its profile of action might be predictive of safer effects in humans as a novel antiobesity treatment.
| Item Type: | Article |
|---|---|
| Subjects: | 500 Scienze naturali e Matematica 500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia |
| Depositing User: | PhD Roberto Coccurello |
| Date Deposited: | 21 Dec 2016 14:11 |
| Last Modified: | 21 Dec 2016 14:11 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/15461 |
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