The expression of the high mobility group HMGI(Y) proteins correlates with the malignant phenotype of human thyroid neoplasias

Chappetta, Gennaro and Bandiera, Antonella and Berlingieri, Maria Teresa and Visconti, Roberta and Manfioletti, Guidalberto and Battista, Sabrina and Martinez-Tello, Francisco J. and Santoro, Massimo and Giancotti, Vincenzo and Fusco, Alfredo (1995) The expression of the high mobility group HMGI(Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. Oncogene, 10. pp. 1307-1314. ISSN 0950-9232

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Abstract

High Mobility Group I (HMGI) proteins are nuclear proteins involved in the regulation of chromatin structure and function. Elevated expression of the HMGI proteins (HMGI, HMGY and HMGI-C) has been correlated with the presence of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells, and in several experimental carcinomas. Here, we demonstrate that HMGI and HMGY proteins are expressed in human thyroid carcinomas and thyroid carcinoma cell lines, but not in adenomas, goiters, normal thyroid tissues and cells. These results indicate a correlation between HMGI and HMGY expression and the malignant phenotype of thyroid neoplasias, suggesting that these proteins may be used as markers in thyroid cancer

Item Type:	Article
Uncontrolled Keywords:	Carcinomas, HMGI (Y) proteins, Immunohistochemistry, Thyroid, Tumor marker
Subjects:	500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia
Depositing User:	Dr Roberta Visconti
Date Deposited:	11 Jan 2017 15:49
Last Modified:	11 Jan 2017 15:49
URI:	http://eprints.bice.rm.cnr.it/id/eprint/15825

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