Bottigli, U. and Brunetti, A. and Carpinelli, M. and Diaz, N. and Fiori, P. L. and Golosio, B. and Masala, G. L. and Oliva, P. and Randaccio, P. and Santona, S. and Zamai, L. and Centis, F. and Valentini, M. and Cesarini, W. and Canonico, B. and Grianti, F. and Balata, M. and Nisi, S. and Laubenstein, M. and Papa, S. and Bedogni, R. and Esposito, A. and Cherubini, Roberto and De Nadal, V. and Gerardi, S. (2008) Effect of cryo-preservation on the response of different biological systems to γ-ray exposure: A feasibility study. Il nuovo cimento C, 31 (1). pp. 11-20. ISSN 1826-9885
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Abstract
Cryopreservation of cells, tissues or organisms (i.e. the storage at liquid-nitrogen or nitrogen vapour temperature) offers the most secure form of preservation, allowing cells to be maintained unaltered for a long time and preventing them from ageing. On the other hand, the multi-year exposure of cryo-preserved cells (like: stem and germ cells) to the environmental γ-ray background might induce a radiation-damage accumulation, due to the inhibition of cellular repair mechanisms, and contribute to cancer or non-cancer pathology risk assessment when such cells should be transplanted in individuals. To investigate the effect of the cryopreservation on the cell response to radiation exposures, the response of different biological systems (bacteria and mammalian cells) to γ-rays has been evaluated after irradiation in cryo-preserved and culture conditions, as a function of dose and doserate, in terms of a variety of cellular and molecular end-points.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Effects of ionizing radiation on biological systems ; Biophysical mechanisms of interaction ; Dosimetry/exposure assessment |
| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 23 Mar 2020 14:43 |
| Last Modified: | 23 Mar 2020 14:43 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/16327 |
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