Ugolini, M. (2014) Perturbation of cellular signaling cascades modulated by ionizing radiation and environmental stress. Il nuovo cimento C, 37 (4). pp. 167-173. ISSN 1826-9885
|
Text
ncc10782.pdf - Published Version Download (354kB) | Preview |
Abstract
Cellular signaling plays a central role in the regulation of several cell functions, which can be perturbed by different external stimuli, including environmental stress and ionizing radiation. The dysregulation of intra- and extracellular mechanisms may alter the correct behaviour of cells. The aim of this work was to investigate the activation of strongly interlaced intracellular signaling pathways, following the exposure to low- and medium-doses of X-rays, with a focus on the mechanisms involved in the inflammatory- and apoptotic-related responses. In particular, the temporal dynamics of the ERK1/2 and PKB/AKT pathways and their possible dose dependences were investigated. The presented results indicate a clear dose dependence of such pathways only at early time points, suggesting a fast response of the system to X-rays and the need for further studies at shorter times after exposures.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Effects of ionizing radiation on biological systems ; Effects of electromagnetic and acoustic fields on biological systems |
| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 19 May 2020 16:04 |
| Last Modified: | 19 May 2020 16:04 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/18649 |
Actions (login required)
 |
View Item |
