Evaluating normal tissue damage after hadrontherapy by chromosome aberration prediction

Embriaco, A. and Brazzorotto, G. and Carante, M. P. and Ferrari, A. and Mairani, A. (2020) Evaluating normal tissue damage after hadrontherapy by chromosome aberration prediction. Il nuovo cimento C, 43 (6). pp. 1-11. ISSN 1826-9885

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Abstract

In cancer hadrontherapy, the Relative Biological Effectiveness (RBE) is calculated by considering cell survival as the endpoint of interest. Although this is a good estimator of the beam effectiveness in eliminating the tumour cells, late damage in healthy tissues, including secondary tumours, is better correlated with chromosomal aberrations. In particular, dicentrics in blood lymphocytes are widely considered as a good biomarker of normal tissue damage, as the blood circulates in all tissues and is inevitably exposed to radiation during the treatment. In this study, lymphocyte dicentrics were used as an ad hoc endpoint to evaluate the RBE for (late) normal tissue damage by means of BIANCA (BIophysical ANalysis of Cell death and chromosome Aberrations), a biophysical model that simulates radiationinduced chromosome aberrations and cell death. More specifically, BIANCA was applied to produce a radiobiological database that predicts lymphocyte dicentric induction as a function of dose, particle type and LET. Afterwards, an interface with the FLUKA code allowed predicting dicentric RBE along a C-ion SOBP, and comparing it with cell survival RBE. This pilot study suggested that using the RBE for tumour cell survival along the entire beam might lead to an underestimation of the risk of normal tissue damage.

Item Type:	Article
Subjects:	500 Scienze naturali e Matematica > 530 Fisica
Depositing User:	Marina Spanti
Date Deposited:	18 Mar 2021 09:34
Last Modified:	18 Mar 2021 09:34
URI:	http://eprints.bice.rm.cnr.it/id/eprint/20874

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