Koepf, Uta S and Klehr, Hans U and Eis-Huebinger, Anna-M and Aldabbagh, Souhaib and Strassburg, Christian P and Boes, Dominik and Lutz, Philipp (2020) Suppression of CMV Infection with Letermovir in a Kidney Transplant Patient. European Journal of Case Reports in Internal Medicine, 7 (7). pp. 1-4. ISSN ISSN: 2284-2594
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Abstract
Infection with cytomegalovirus (CMV) with resistance to ganciclovir (GCV) is a therapeutic challenge in kidney transplant patients, because standard treatment options are nephrotoxic. We report the case of a kidney transplant recipient with GCV-resistant CMV disease, in whom letermovir, a novel inhibitor of CMV packaging, was administered off-label and prevented a relapse of disease once the CMV load was decreased by cidofovir. Furthermore, we observed significant drug interactions between letermovir and tacrolimus.
| Item Type: | Article |
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| Uncontrolled Keywords: | Cytomegalovirus, kidney transplantation, UL97 mutation, antiviral resistance, letermovir |
| Subjects: | 600 Tecnologia - Scienze applicate 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 14 Dec 2021 14:34 |
| Last Modified: | 14 Dec 2021 14:34 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/20928 |
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