Amado, Carolina and Ferreira, Gisela and Silva, Fernando and Silva Leal, Mariana and Cruz, Margarida (2020) Encephalopathy after Bendamustine Treatment: A Rare Side Effect? European Journal of Case Reports in Internal Medicine, 7 (12). pp. 1-2. ISSN ISSN: 2284-2594
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Abstract
Bendamustine is a chemotherapeutic drug associated with frequent haematological and gastrointestinal adverse effects and, more rarely, neurological toxicity.We present the case of a 79-year-old man with follicular lymphoma, grade 2, Ann-Arbor stage IV-A, FLIPI 4, high risk, with bulky disease and vital organ compression, treated with R-CHOP and then rituximab-bendamustine, who developed encephalopathy approximately 2 months after the last cycle. After ruling out other possible aetiologies, we assumed the patient’s encephalopathy was due to a delayed bendamustine side effect, possibly aggravated by the concomitant administration of rituximab.The authors hope to alert clinicians to this rare adverse effect, its difficult identification and the need to rule out other aetiologies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Follicular lymphoma, bendamustine, rituximab, neurotoxicity, encephalopathy |
| Subjects: | 600 Tecnologia - Scienze applicate 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 20 Dec 2021 14:33 |
| Last Modified: | 20 Dec 2021 14:33 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21127 |
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