Borio, Giorgia and Terracciano, Chiara and Buttafava, Federico and Vercelli, Andrea and Pagani, Laura and Zanzani, Chiara and Manicardi, Alessandra and Magnacavallo, Andrea and Poggiali, Erika (2021) Skin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease. European Journal of Case Reports in Internal Medicine, 8 (10). pp. 1-6. ISSN 2284-2594
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Abstract
We report the case of a 62-year-old male patient fully vaccinated for COVID-19, admitted to our emergency room for persistent fever associated with exertional dyspnoea, skin lesions, diffuse myalgias and arthralgias not responsive to broad-spectrum antibiotic and antiviral therapy, who developed a rapidly progressive refractory to treatment interstitial lung disease due to anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, that required mechanical ventilation and ECMO. Here, we highlight the importance of always considering alternative diagnoses, i.e. viral and autoimmune diseases, including anti-MDA5 antibody screening, when dealing with patients with a skin rash, seronegative polyarthralgias and interstitial pneumonia, or acute respiratory distress syndrome of unknown origin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MDA5-associated dermatomyositis, MDA5-associated interstitial lung disease, interstitial pneumonia, dyspnoea |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 17 Feb 2022 12:05 |
| Last Modified: | 17 Feb 2022 12:05 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21724 |
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