Adamski, Jan and Jäschke, Björn and Nieminen, Tuomas and Weigl, Wojciech (2021) Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra. European Journal of Case Reports in Internal Medicine, 8 (10). pp. 1-4. ISSN 2284-2594
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Abstract
We report the use of anakinra to treat a case of a 64-year-old man diagnosed with haemophagocytic lymphohistiocytosis (HLH) with neurological involvement. After the administration of intravenous pulse corticosteroid therapy, immunoglobulin and anakinra the patient showed neurological recovery. However, the recovery was complicated by the perforation of a pre-existing bowel diverticulum. The effect of anakinra on bowel inflammation has not yet been clearly established. It can potentially augment bowel inflammation and contribute to the risk of bowel perforation associated with the concomitant use of corticosteroids.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Diverticulitis, haemophagocytic lymphohistiocytosis (HLH), gut, interkeukin-1 (IL-1) receptor antagonist, gastrointestinal diseases |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 17 Feb 2022 12:06 |
| Last Modified: | 17 Feb 2022 12:06 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21727 |
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