An open-label pilot study of the use of rivastigmine to promote functional recovery in patients with unilateral spatial neglect due to first ischemic stroke

Paolucci, Stefano and Bureca, Ivana and Multari, Mirella and Nocentini, Ugo and Matano, Alessandro (2010) An open-label pilot study of the use of rivastigmine to promote functional recovery in patients with unilateral spatial neglect due to first ischemic stroke. Functional Neurology; New Trends in Interventional Neurosciences, 25 (4). pp. 195-200. ISSN 1971-3274

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Abstract

The aim of this study was to evaluate the efficacy and safety of rivastigmine as add-on treatment to specific cognitive rehabilitation for unilateral spatial neglect (USN). Twenty patients were randomly assigned either to rehabilitation treatment only (No-RIV) or to rivastigmine (3 mg twice a day, for 8 weeks) add-on treatment (RIV+,). USN and functional status were evaluated by means of specific and validated instruments at baseline, at discharge and at one-month follow up. Compared with the untreated patients, the RIV+ subjects, at discharge, recorded significantly better discharge scores and higher effectiveness on two of the scales. However, subsequent further improvement of the No-RIV patients meant that at follow up there was no significant difference between the two groups. No other statistically significant difference was found. Rivastigmine as add-on treatment to specific cognitive training for USN may improve and accelerate recovery on some specific impairment tests as compared with cognitive training alone

Item Type:	Article
Uncontrolled Keywords:	Neglect, rehabilitation, rivastigmine, stroke
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.81 Sistema nervoso - Malattie cerebrovascolari (Classificare qui l’Apoplessia cerebrale, l'Ischemia cerebrale, Ictus cerebrale) > 616.8106 Sistema nervoso - Malattie cerebrovascolari – Riabilitazione
Depositing User:	Danilo Dezzi
Date Deposited:	01 Jun 2012 15:17
Last Modified:	01 Jun 2012 15:17
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3580

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