Genes and the dynamics of pain control

Hunt, Stephen P. (2009) Genes and the dynamics of pain control. Functional Neurology; New Trends in Interventional Neurosciences, 24 (1). pp. 9-15. ISSN 1971-3274

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Abstract

There are well-documented sex differences in the prevalence of various painful disorders. To comprehend the mechanisms underlying these differences requires an understanding of the molecular organisation and systems biology that are responsible for the pain experience. The pain system evolved to secure the survival of the animal under a variety of environmental constraints and needed to be flexible enough to compete against other behavioural needs and homeostatic demands. From the periphery to the cortex, mechanisms exist to facilitate or inhibit nociceptive signalling and it is this inherent plasticity that is thought to be perturbed in chronic pain states. There is limited evidence to suggest that polymorphisms or mutations in certain genes and gender can influence the pain experience but it seems likely that epigenetics and the influence of past experience are responsible for a substantial part of the variation between sexes and between individuals

Item Type:	Article
Uncontrolled Keywords:	Descending control, local translation, MeCP2, pain, sensitisation
Subjects:	500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia > 571 Fisiologia e soggetti connessi (Classificare qui le opere d'insieme sui processi biologici interni) > 571.6 Biologia cellulare (Classificare qui la Fisiologia cellulare, la Citologia, le cellule eucariotiche, il protoplasma) 500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia > 572 Biochimica (Classificare qui la Citochimica, l'Istochimica, le opere d'insieme su Biochimica e Biofisica; le opere interdisciplinari sulle sostanze biochimiche, sulle macromolecole) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User:	Danilo Dezzi
Date Deposited:	23 Feb 2012 09:05
Last Modified:	23 Feb 2012 09:05
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3590

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