Depression in women with epilepsy: clinical and neurobiological aspects

Cavanna, Andrea Eugenio and Cavanna, Stefano and Bertero, Luca and Robertson, Mary May (2009) Depression in women with epilepsy: clinical and neurobiological aspects. Functional Neurology; New Trends in Interventional Neurosciences, 24 (2). pp. 83-87. ISSN 1971-3274

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Abstract

Patients affected by epilepsy show a considerably higher incidence of depression compared with the general population. Since women are twice as likely as men to suffer from depression, female gender could be considered a major risk factor for developing this condition. Converging lines of evidence suggest that sex hormones, which are known to contribute to remodelling the hippocampus, play a pivotal role in both epilepsy and depression. In women, the role of sex hormone levels may be more important because of their physiological cyclic fluctuations. Oestrogens, more than other ovarian hormones, show an effect similar to antidepressant drugs by stimulating hippocampal synaptogenesis, thus exerting a protective role against seizures as well. This paper reviews the current knowledge on the neurobiological basis of depression in women with epilepsy. The emerging picture informs therapeutic strategies to improve the clinical management of this common comorbidity

Item Type:	Article
Uncontrolled Keywords:	Antiepileptic drugs, depression, epilepsy, sex hormones, SSRIs, women
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.85 Malattie varie del sistema nervoso e disturbi mentali di diverso genere > 616.853 Epilessia
Depositing User:	Danilo Dezzi
Date Deposited:	22 Feb 2012 14:09
Last Modified:	22 Feb 2012 14:09
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3611

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