Plasma melatonin pattern in chronic and episodic headaches. Evaluation during sleep and waking

Bruera, Osvaldo and Sances, Grazia and Leston, Jorge and Levin, Gloria and Cristina, Silvano and Medina, Carlos and Barontini, Marta and Nappi, Giuseppe and Figuerola, María de Lourdes (2008) Plasma melatonin pattern in chronic and episodic headaches. Evaluation during sleep and waking. Functional Neurology; New Trends in Interventional Neurosciences, 23 (2). pp. 77-81. ISSN 1971-3274

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Abstract

To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH) (during active and remission periods), chronic tension-type headache (CTTH) patients and controls during NREM sleep, REM sleep and waking, we performed serial sampling of plasma melatonin in the different sleep stages during the first half of the night, in order to avoid chronobiological interferences. Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. A trend to normalization of the curve during the remission period was observed. On the basis of these different melatonin secretion patterns, it might be hypothesized that the involvement of the hypothalamus in chronic-type headaches differs from that displayed in episodic forms.

Item Type:	Article
Uncontrolled Keywords:	Chronic migraine, chronic tension-type headache, cluster headache, melatonin, sleep stages
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User:	Danilo Dezzi
Date Deposited:	08 Jan 2013 14:36
Last Modified:	08 Jan 2013 14:36
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3679

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