Cerebral blood flow changes in patients with probable medication-overuse headache

Savrun, Feray Karaali and Goksan, Baki and Savrun, Mert and Sahin, Rahsan and Sahin, Sevki (2008) Cerebral blood flow changes in patients with probable medication-overuse headache. Functional Neurology; New Trends in Interventional Neurosciences, 23 (2). pp. 83-86. ISSN 1971-3274

PDF portiere.pdf - Published Version Restricted to Repository staff only Download (67kB)

Abstract

Transcranial Doppler (TCD) is a non-invasive method for measuring blood flow velocity (BFV), and a marker of vessel diameter. In this study, intracranial BFV was investigated, by means of TCD, in patients suffering from probable medication-overuse headache (PMOH). Twenty-three female patients with probable ergotamine-overuse headache (PEOH), 23 female patients with probable analgesic-overuse headache (PAOH), and 15 healthy female controls participated in the study. The mean BFVs of the bilateral middle and anterior cerebral arteries (MCA and ACA) and basilar artery (BA) were measured by TCD. The mean BFVs of the BA and MCA were found to be significantly increased in the PEOH group when compared with those of the PAOH and control groups (p<0.05). No significant differences in BFV of the ACA were observed between any groups (p>0.05). The mean BFV of all the vessels in the PAOH group was found to be lower than that of the control group but no statistical significance was found (p>0.05). Our results show that ergotamine increases BFV via vasoconstriction, especially of the BA and MCA. We also suggest that 5HT1B/1D receptors are mainly localized in the BA and MCA, and that analgesic overuse results in a functional disorder of neuronal receptor and neurovascular reflexes and may cause a reduction of intracerebral vessel tone, leading to vasodilatation

Item Type:	Article
Uncontrolled Keywords:	Analgesic, cerebral blood flow, headache, ergotamine, overuse, transcranial Doppler
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.8047548 Sistema Nervoso – Risonanza magnetica nucleare (Classificare qui: Neuroimaging, Neuroimaging funzionale, Cervello - Risonanza magnetica funzionale, Cervello - Risonanza magnetica per immagini) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.84 Manifestazioni delle malattie neurologiche (Classificare qui la patologia, la diagnosi, il trattamento dei sintomi) > 616.849 Sintomi vari (Include il coma, il dolore, l’enuresi, disturbi della coscienza) > 616.8491 Cefalea
Depositing User:	Danilo Dezzi
Date Deposited:	18 Jul 2012 11:23
Last Modified:	18 Jul 2012 11:23
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3680

Actions (login required)

View Item