Neuropsychological impairment and the natural history of HIV-1 infection in Spanish subjects

Rodríguez Alvarez, Marina Xose and Faílde Garrido, José María and Simón López, Miguel Angel (2007) Neuropsychological impairment and the natural history of HIV-1 infection in Spanish subjects. Functional Neurology; New Trends in Interventional Neurosciences, 22 (3). pp. 165-170. ISSN 1971-3274

PDF portiere.pdf - Published Version Restricted to Repository staff only Download (52kB)

Abstract

The authors set out to determine the rates and pattern of neuropsychological impairment shown by seropositive Spanish patients in different stages of HIV infection. A clinical sample was recruited consisting of 115 heterosexual subjects (30 seropositive asymptomatic; 17 seropositive in stage B; 41 seropositive with AIDS, and 27 seronegative). All subjects provided written informed consent and were submitted to the same process of evaluation. A rate of neuropsychological impairment of 33.3% was found in stage A (asymptomatic patients); of 41.2% in stage B (low symptomatology patients); and of 70.7% in stage C (AIDS patients). The pattern of neuropsychological impairment shown by the AIDS patients was qualitatively similar to that observed in the asymptomatic subjects, and consistent with fronto-subcortical-type alterations. Clinically asymptomatic HIV infection represents a risk factor for neuropsychological impairment, even though our results reinforce the idea that the impairment seen in the asymptomatic stages cannot be interpreted as a predictor of more severe cognitive deficits as the disease progresses.

Item Type:	Article
Uncontrolled Keywords:	AIDS, asymptomatic HIV infection, HIV infection, neuropsychological impairment, stage of infection.
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.89 Disturbi psichici (Classificare qui Psicologia patologica e clinica, Psichiatria, Psichiatria computazionale, Neuropsicologia, il comportamento anormale comparato degli animali, le psicosi) (Include le manifestazioni dei disturbi mentali) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.9 Altre malattie (altri rami della Medicina) > 616.97 Malattie del sistema immunitario > 616.979 Malattie da deficienza immunitaria > 616.9792 Sindrome da deficienza immunitaria acquisita (AIDS) (Classificare qui le infezioni da HIV - Human Immunodeficiency Virus)
Depositing User:	Danilo Dezzi
Date Deposited:	30 Jan 2012 13:03
Last Modified:	30 Jan 2012 13:03
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3734

Actions (login required)

View Item