Oral manifestations in the Graft versus Host Disease in paediatric patients: case report

Maturo, Paolo and Condò, Roberta and Costacurta, Micaela and Docimo, R. (2009) Oral manifestations in the Graft versus Host Disease in paediatric patients: case report. Oral & implantology, 2 (2). pp. 34-41. ISSN 2035-2468

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Abstract

Graft-versus-Host Disease (GvHD) syndrome is characterized by specific pathologic and immunologic clinical manifestations, induced by the transplantation, in a body with compromised immune system, of immunologically active T lymphocytes belonging to a donor whose genome is different from the recipient. GvHD can be clinically classified into two forms: acute (aGvHD), if it is induced only by the cytotoxic effect of the donor T lymphocytes in host tissues and chronic (cGvHD), when it is caused by a cytotoxic effect associated with severe immunodeficiency.Patients affected by GvHD frequently develop a massive and progressive involvement of the oral mucosa, being so severe to impair normal feeding as well.The Authors hereby introduce a GvHD clinical case in a 12-year-old patient who underwent Hematopoietic Stem Cell Transplantation (HSCT) from a compatible donor, with odonto-stomatological diseases induced by the syndrome. Early diagnosis and a multidisciplinary treatment plan in the initial phases of this complex and dynamic syndrome are key factors to improve the quality of life in these patients.

Item Type:	Article
Uncontrolled Keywords:	Oral manifestations, GvHD, paediatric patient
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia > 617.6 Odontoiatria
Depositing User:	Nadia Del Gobbo
Date Deposited:	02 Apr 2013 14:20
Last Modified:	14 May 2013 14:14
URI:	http://eprints.bice.rm.cnr.it/id/eprint/4826

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