Antiphospholipid Syndrome during pregnancy: the state of the art

Di Prima, Fosca A. F. and Valenti, Oriana and Hyseni, Entela and Giorgio, Elsa and Faraci, Marianna and Renda, Eliana and De Domenico, Roberta and Monte, Santo (2011) Antiphospholipid Syndrome during pregnancy: the state of the art. Journal of prenatal medicine, 5 (2). pp. 41-53. ISSN 1971-3290

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Abstract

Obstetric complications are the hallmark of antiphospholipid syndrome. Recurrent miscarriage, early delivery, oligohydramnios, prematurity, intrauterine growth restriction, fetal distress, fetal or neonatal thrombosis, pre-eclampsia/eclampsia, HELLP syndrome, arterial or venous thrombosis and placental insufficiency are the most severe APS-related complication for pregnant women. Antiphospholipid antibodies promote activation of endothelial cells, monocytes and platelets, causing an overproduction of tissue factor and thromboxane A2. Complement activation might have a central pathogenetic role. These factors, associated with the typical changes in the hemostatic system during normal pregnancy, result in a hypercoagulable state. This is responsible of thrombosis that is presumed to provoke many of the pregnancy complications associated with APS. Obstetric care is based on combined medical-obstetric high-risk management and treatment with the association between aspirin and heparin. This review aims to deter- mine the current state of the art of APS by investigating the knowledge achievements of recent years, to provide the most appropriate diagnostic and therapeutic management for pregnant women suffering from this syndrome.

Item Type:	Article
Uncontrolled Keywords:	Antiphospholipid, thrombophilia, hypercoagulability, thromboprophylaxis
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 618 Altri rami della medicina; Ginecologia e ostetricia, Pediatria, Geriatria > 618.3 Malattie e complicazioni della gravidanza
Depositing User:	Gianni Aiello
Date Deposited:	20 May 2013 16:44
Last Modified:	20 May 2013 16:44
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5180

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