Continuous intestinal infusion oflevodopa/carbidopa in advanced Parkinson’sdisease: efficacy, safety and patient selection

Abruzzese, Giovanni and Barone, Paolo and Bonuccelli, Ubaldo and Lopiano, Leonardo and Antonini, Angelo (2012) Continuous intestinal infusion oflevodopa/carbidopa in advanced Parkinson’sdisease: efficacy, safety and patient selection. Functional Neurology : New Trends in Interventional Neurosciences, XXVII (3). pp. 147-154. ISSN 0393-5264

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Abstract

Long-term oral therapy with levodopa is associatedwith the development of motor fluctuations and dyski-nesia in a large percentage of patients with Parkinson’sdisease (PD). Motor complications are associated witha number of non-motor symptoms and have a negativeimpact on disability and quality of life. There are threetherapeutic options available for the management ofpatients at this advanced stage: high frequency deepbrain stimulation, continuous subcutaneous infusionof apomorphine, and continuous intestinal infusion oflevodopa/carbidopa. On the basis of published dataand in consideration of the risk-benefit profile of cur-rent therapeutic strategies, we here propose an algo-rithm to help clinicians select the most suitable treat-ment option for patients with advanced PD.

Item Type:	Article
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) 600 Tecnologia - Scienze applicate > 620 Ingegneria e attivita' affini
Depositing User:	Chiara Bisogno
Date Deposited:	03 May 2013 12:57
Last Modified:	10 Sep 2019 14:44
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5200

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