Kidney complications in primary hypercalciuria

Vezzoli, Giuseppe and Arcidiacono, Teresa and Bianchin, Cristiana and Terranegra, Annalisa and Soldati, Laura (2004) Kidney complications in primary hypercalciuria. Clinical cases in mineral and bone metabolism, 1 (1). pp. 35-39. ISSN 1971-3266

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Abstract

Prevalence of hypercalciuria is markedly increased in patients with calcium kidney stones, and recently it has been demon- strated that the risk to produce stones is positively related with the levels of calcium excretion in general population. The stone- promoting effect of hypercalciuria depends on the unusually high calcium concentrations in urine and tubular fluid, which fa- vor calcium salt precipitation. However, the specific role of calci- um in the pathogenetic pathway leading to stone formation has not been elucidated and it is unclear whether initial events of this process develop in tubules or in papillary interstitium. Nephrocalcinosis occurs in the course of many hereditary or acquired disorders having hypercalciuria as the common alter- ation and can progressively damage kidney function. In spite of the relevance of hypercalciuria for nephrocalcinosis, the specif- ic effect of calcium in its development is yet unknown. An increased frequency of hypercalciuria has also been recorded among patients with arterial hypertension. It has been hypothesized that a body calcium deficiency is induced by hypercalciuria and leads to the elevation of blood pressure. This may be true in a subgroup of patients, while hypercalci- uria is likely to occur more commonly in patients with volume- dependent hypertension. Irrespective of its possible causal role, hypercalciuria may predict individual susceptibility to stones, nephrocalcinosis or arterial hypertension. Measurement of 24 hour calcium excre- tion could become an instrument to identify subjects predis- posed to these disorders.

Item Type:	Article
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User:	Patrizia Romano
Date Deposited:	19 Mar 2014 15:07
Last Modified:	19 Mar 2014 15:07
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5515

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