Chirurgia per carcinoma gastrico in area ad elevata incidenza: studio retrospettivo

Mura, G. and Attolini, G. and Schurfeld, Karin and Tauceri, F. and Renzi, F. and Taddeucci, S. and Minisci, Davide and Cangioni, G. (2009) Chirurgia per carcinoma gastrico in area ad elevata incidenza: studio retrospettivo. Il giornale di chirurgia, 30 (5 Supp). pp. 111-117. ISSN 1971-145X

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Abstract

Background and aims: Gastric cancer (GC) remains one of most worldwide frequent cancers. In Eastern Tuscany (Italy), the areas close to mountains are high-risk areas, with GC incidence and mortality significantly higher than in rest of Italy and Western European Countries. The experience in gastric surgery from a little-sized hospital located in high-risk area is reported. Methods: From 2000 to 2008, 206 patients (mean age 74.3 yrs) were diagnosed for GC. 35% of them were already in far-advanced and metastatic stage and not operated on. Surgery, post-operative mortality and morbidity, clinico-pathologic features and actuarial cumulative survival (Kaplan-Meier) were retrospectively analyzed; uni- (log rank) and multi-variated analysis (Cox’s regression) were performed. Results: In 78.8% of patients submitted to operation, radical surgery was achieved. The mean excised nodes were 31.8; only in 11% of cases less than 15 nodes were excised. Median overall survival (OS) was 51.2 mos for radical surgery vs 4.2 of palliative surgery and 5.5 of no surgery. The lympho-nodal status, the T-status, the N ratio, hystology according Lauren’s, UICC stage were all correlated with survival at univariated analysis. N ratio, N status and T status were independent prognostic factors also at Cox’s multivariated analysis. Conclusion: Endoscopic screening is desiderable in high-risk areas for GC. In the treatment of gastric cancer, radical surgery plays a lead role, but the recurrence rate is high even after curative surgery combined with extended nodal dissection. Multimodal treatments should be considered in the treatment of these patients.

Item Type:	Article
Uncontrolled Keywords:	Gastric cancer, surgery, survival, chemotherapy neo-adjuvant
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User:	Nadia Del Gobbo
Date Deposited:	09 Feb 2016 17:09
Last Modified:	09 Feb 2016 17:09
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5902

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