The role of the immune system in the physiopathology of osteoporosis

Cagnetta, Valentina and Patella, Vittorio (2012) The role of the immune system in the physiopathology of osteoporosis. Clinical cases in mineral and bone metabolism, 9 (2). pp. 85-88. ISSN 1971-3266

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Abstract

The close anatomical relationship between the immune system, estrogen deficiency and bone loss has been recognized for centuries but the existence of a functional relationship has emerged only recently. The role of the immune system in the development of senile osteoporosis, which arises primarily through the effects of estrogen deficiency and secondary hyperparathyroidism, is slowly being unraveled. This review focuses the evidence that links immune cells, inflammation, cytokine production and osteoclast formation and their activity. The under standing of the interplay of inflammation and osteoclast can lead to the development of new drugs for prevention and treatment of bone loss

Item Type:	Article
Uncontrolled Keywords:	Osteoporosis; immune system; osteoclast; cytokines; T cells; B cells
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User:	Danilo Dezzi
Date Deposited:	03 Dec 2013 15:00
Last Modified:	03 Dec 2013 15:00
URI:	http://eprints.bice.rm.cnr.it/id/eprint/6039

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