Biochemical markers as predictors of bone remodelling in dental disorders: a narrative description of literature

Duvina, Marco and Barbato, Luigi and Brancato, Leila and Delle Rose, Giovanna and Amunni, Franco and Tonelli, Paolo (2012) Biochemical markers as predictors of bone remodelling in dental disorders: a narrative description of literature. Clinical cases in mineral and bone metabolism, 9 (2). pp. 100-106. ISSN 1971-3266

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Abstract

Osteoporosis is a systemic disease in which the skeletal condition is characterized by a decreased mass of normally mineralized bone, due to an augmentation of bone resorption processes. Bone biomarkers serum are used for the diagnosis. On the other hand the main cause of the resorption in the bone jaws are periodontitis, inflammatory cysts, developmental cysts, odontogenic neoplasms. Periodontal diseases can be localized to a single site of the jaws or can affect all the teeth, with a massive bone resorption. The cysts are classified in developmental and inflammatory. They caused a local bone resorption in the jaws. Keratocystic odontogenic tumor produces a large bone resorption for its local aggressive nature. Their diagnosis is clinical and radiological. The aim of our review is to find a correlation between bone biomarkers serum and periodontitis, inflammatory cists, developmental cysts, odontogenetic neoplasms. The RANK/RANKL/OPG system is the most studied not only in osteoporosis but also in the periodontitis, inflammatory cysts, developmental cysts, odontogenic neoplasms. In the last years osteoimmunology was used to study the periodontal disease progression, because the immunity cells start the bone resorption processes. A lot of studies analyze the biomarkers present in the biofluids, as saliva and gingival crevicular fluid, but not the correlation with serum biomarkers. Future studies must be organized to deepen the correlation between bone biomarkers and bone jaws resorption and to allow diagnosis and prognosis of periodontitis, inflammatory cysts, developmental cysts, odontogenic neoplasms

Item Type:	Article
Uncontrolled Keywords:	Osteoporosis; periodontitis; odontogenic cyst; serum marker; Rankl
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User:	Danilo Dezzi
Date Deposited:	03 Dec 2013 14:38
Last Modified:	03 Dec 2013 14:41
URI:	http://eprints.bice.rm.cnr.it/id/eprint/6043

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