The genetic profile of bone repair

Dimitriou, Rozalia and Giannoudis, Peter V. (2013) The genetic profile of bone repair. Clinical cases in mineral and bone metabolism, 10 (1). pp. 19-21. ISSN 1971-3266

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Abstract

Bone repair following a fracture is a complex, well orchestrated, physiological process in response to injury. Even though the exact number of the genes and expressed proteins involved in fracture healing remains unknown, the molecular complexity of the repair process has been demonstrated, and it involves numerous genes and molecules, such as extracellular matrix genes, growth and differentiation factors, matrix metalloproteinases, angiogenic factors and others. Discrepancies in fracture healing responses and final outcome seen in the clinical practice may be attributed among other factors to biological variations between patients and different genetic “profiles”, resulting in “altered” signalling pathways that regulate the bone repair process. Preliminary human studies support a “genetic” component in the pathophysiology of impaired bone repair seen in atrophic non-unions by correlating genetic variations of specific molecules regulating fracture healing with nonunion. However, the role of the genetic “profile” of each individual in fracture healing and final outcome, and its possible interaction with other exogenous factors remains a topic of extensive research

Item Type:	Article
Uncontrolled Keywords:	Genetic profile, genetic variation, bone repair, fracture healing
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User:	Danilo Dezzi
Date Deposited:	28 Nov 2013 13:19
Last Modified:	28 Nov 2013 13:19
URI:	http://eprints.bice.rm.cnr.it/id/eprint/6104

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