Un caso di neoplasia gastrica metastatica trattato con successo con chirurgia e chemioterapia

Gunnellini, Marco and Graziosi, Luigina and Emili, Rita and Bugiantella, Walter and Ferrazza, Patrizia and Cavazzoni, Emanuel and Donini, Annibale and Liberati, Anna Maria (2010) Un caso di neoplasia gastrica metastatica trattato con successo con chirurgia e chemioterapia. Il giornale di chirurgia, 31 (8/9). pp. 375-378. ISSN 1971-145X

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Abstract

A case of long-term survivor 50-year-old man treated for advanced gastric cancer with two liver metastases is described. Patient underwent a total gastrectomy with D2 lymphadenectomy and atipic liver resection. After surgery, chemotherapy with PELF achieved a complete clinical response; six month from the fourth cycle, Ca19.9 levels slowly increased until 185 U/mL and a retro-peritoneal lymphadenopathy was detected by US. Three different chemoterapic combinations (FOLFOX, FOLFIRI, FOLFOX4) was administrated but two new liver recurrences spread out. From November 2007 until now, patient received 8 CDF cycles and he obtained a complete clinical response supported by persistent negativity of TC-PET scans. The radiological investigations performed after last admission in our Department for jaundice, revealed multiple liver lesions with Ca19.9 levels of 6.766 U/mL. The patient required placement of metallic biliary endoprosthesis. He is still alive 41 month after primary surgery. We consider this case a successful example of survival increasing by integrated surgery-chemotherapy treatment but also an expression of the failure of current available therapy in the definitive cure for gastric cancer. Metastatic gastric cancer should be considered a disease treatable but not curable.

Item Type:	Article
Uncontrolled Keywords:	Neoplasia dello stomaco - Metastasi epatiche - Chemioterapia - Chirurgia
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User:	Nadia Del Gobbo
Date Deposited:	20 Apr 2016 14:42
Last Modified:	20 Apr 2016 14:42
URI:	http://eprints.bice.rm.cnr.it/id/eprint/7116

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