Human Muscle-Derived Stem Cells. Effectiveness in animal models of faecal incontinence. Research scheduling

Mongardini, Massimo and Lisi, Antonella and Giofrè, Manuel and Ledda, Mario and Grimaldi, Settimio and Scarnò, Marco and Trucchia, Alessio and Kiriacou, A.K. and Badiali, D. and Custureri, Filippo (2011) Human Muscle-Derived Stem Cells. Effectiveness in animal models of faecal incontinence. Research scheduling. Il giornale di chirurgia, 32 (8/9). pp. 357-360. ISSN 1971-145X

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Abstract

Researchers believe that human muscle-derived cells are able to restore leak-point pressure to normal levels by differentiating into new muscle fibres that prevent anal sphincter muscle atrophy. Laboratory data are needed to identify exactly how these cells work to regenerate muscle. The objective of this study is to test whether stem cells can be employed to treat internal anal sphincter (IAS) injuries in humans; to this end, this work will use a two-step process to study: first, the effectiveness of the treatment in a sample of animals with artificial injuries to the IAS and then to verify the results in a population of selected humans affected by pathology.

Item Type:	Article
Uncontrolled Keywords:	Faecal incontinence - Muscle-Derived Stem Cells - Electromyography - Anal pressure - Sphincterotomy - Pudendal nerve
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User:	Nadia Del Gobbo
Date Deposited:	06 May 2016 12:56
Last Modified:	06 May 2016 12:56
URI:	http://eprints.bice.rm.cnr.it/id/eprint/7648

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