The efficacy of Iloprost for the treatment of chronic venous ulcers of the lower limbs

Conciglia, Aldo and Mandolfino, Tommaso and D'Alfonso, Mario (2011) The efficacy of Iloprost for the treatment of chronic venous ulcers of the lower limbs. Il giornale di chirurgia, 32 (10). pp. 434-437. ISSN 1971-145X

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Abstract

ackground. The purpose of this study was to assess the effect of Iloprost in the treatment of venous ulcers. Patients and methods. We recruited 52 patients with uncomplicated venous ulcers of the lower limbs. They were divided into two groups: the first (29 patients) was given Iloprost in saline solution for three weeks, while the second (23 patients) received saline solution only. The size and number of ulcers were determined at the start of the treatment and then every 15 days for six months. Results. Ulcer size diminished faster in the patients treated with Iloprost, with 100% healed within 120 days. In the placebo group, 82.60% had healed by the end of the 180-day observation period. This difference was statistically significant. Ulcer cicatrization was also faster in the treatment group (65.51% after 60 days, 86.20% after 90 days and 100% after 120 days), whereas in the placebo group, the ulcers had still not healed in 17.40% of patients by the study end. Conclusions. Iloprost can significantly reduce healing time for venous leg ulcers without any specific complications.

Item Type:	Article
Uncontrolled Keywords:	Venous ulcer - Iloprost - Chronic venous insufficiency
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User:	Nadia Del Gobbo
Date Deposited:	06 May 2016 14:57
Last Modified:	06 May 2016 14:57
URI:	http://eprints.bice.rm.cnr.it/id/eprint/7710

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