Metalloproteases and tendinopathy

Del Buono, Angelo and Oliva , Francesco and Osti, Leonardo and Maffulli, Nicola (2013) Metalloproteases and tendinopathy. M.L.T.J. Muscles, Ligaments and Tendons Journal, 3 (1). pp. 51-57. ISSN 2240-4554

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Abstract

Matrix metalloproteinases (MMP) are involved in the development of tendinopathy. These potent enzymes completely degrade all components of the connective tissue, modify the extracellular matrix (ECM), and mediate the development of painful tendinopathy. To control the local activity of activated proteinases, the same cells produce tissue inhibitors of metalloproteinases (TIMP). These latter bind to the enzyme and prevent degradation. The balance between the activities of MMPs and TIMPs regulates tendon remodeling, whereas an imbalance produces a collagen dis-regulation and disturbances in tendons. ADAMs (a disintegrin and metalloproteinase) are cell membrane-linked enzymes with proteolytic and cell signaling functions. ADAMTSs (ADAM with thrombospondin motifs) are secreted into the circulation and constitute a heterogenous family of proteases with both anabolic and catabolic functions. Further studies are needed to better define the mechanism of action, and whether these new strategies are safe and effective in larger models

Item Type:	Article
Uncontrolled Keywords:	Metalloproteases, tendinopathy, tendon healing
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	17 Apr 2014 11:09
Last Modified:	17 Apr 2014 11:09
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8229

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