The 12-month treatment with the oral contraceptive formulation containing dienogest (DNG) and estradiol valerate (E2V) shows beneficial effects on psychological symptoms: results from a prospective comparative study with a formulation containing ethinyl estradiol (EE) and drospirenone (DRSP)

Fais, Maria Francesca and Malune, Elena and Perseu, Mariagrazia and Orrù, Marisa and Pilloni, Monica and Corda, Valentina and Puletti, Chiara and Abis, Marta and Cornacchia, Stefania and Melis, Gian Benedetto and Paoletti, Anna Maria (2013) The 12-month treatment with the oral contraceptive formulation containing dienogest (DNG) and estradiol valerate (E2V) shows beneficial effects on psychological symptoms: results from a prospective comparative study with a formulation containing ethinyl estradiol (EE) and drospirenone (DRSP). Multidisciplinary Journal of Women's Health (MJWH), 2 (1). pp. 4-5. ISSN 2281-3403

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Abstract

The COCs evolution has been obtained with new and differents progestinic compounds associated with lower doses of EE (ethinylestradiol). The revolution in the COCs field is the introduction of estradiol valerate (E2V), ester of the natural estrogen, estradiol (E2) instead of EE. Dienogest (DNG) is the progestinic compound of the COC Klaira® associated with E2V in a multiphase formulation. DNG has a strong antiandrogenetic action without the mineralcorticoid and glucocorticoid action and E2V acts in this association improving the subjective sleep quality, somatic complaints, anxiety, vigilance, cognition and numerical memory. The EE/DRSP (drospirenone) association (Yaz®) has a progestinic compound characterized by antimineralcorticoid and antiandrogenic properties with a positive effect on psychological symptoms. In this prospective study we evaluated if E2V is able to exert the same psychological symptoms as EE/DRSP formulation. Psychological changes were evaluated with SCL90 for 5 cycles. In comparison with the basal value the score was significantly reduced (p<0,001) during both treatments. This effects observed confirm that DNG and DRSP act with beneficial effects on CNS

Item Type:	Article
Uncontrolled Keywords:	Dienogest, drospirenone, estradiol valerate
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
Depositing User:	Danilo Dezzi
Date Deposited:	18 Apr 2014 10:06
Last Modified:	18 Apr 2014 10:06
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8412

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