Low bone mineral density and high bone turnover in adult subjects with thalassemia major

Sferrazza, Carmela and Rini, Giovan Battista (2005) Low bone mineral density and high bone turnover in adult subjects with thalassemia major. Clinical cases in mineral and bone metabolism, 2 (1). pp. 17-19. ISSN 1971-3266

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Abstract

In this study we evaluated 38 TM patients (recruited from the Thalassemia centre of Palermo), 14 male and 24 female. We obtained the BMD of the lumbar spine (L1 L4), femoral neck (DEXA; Lunar DPX plus), serum levels of PTH, osteocalcin, Ctelopeptide and bone alkaline phosphatase. Patients with TM presented low bone mass at lumbar spine (Z score: L1-L4 -2.23 ± 1.25 SD), and femoral neck (Z-score -1.52 ± 1.14 SD): 50% of subjects were osteoporotic; 36% osteopenics and 13.1% were normal. Were presented normal serum levels of osteocalcin (19.1 ± 8 ng/ml), but hight level of bone alkaline phosphatase (24.2 ± 9.1 g/L), and C-telopeptide (4528 ± 2821 pmol/L). Patients with TM presented BMD reduction more marked at lumbar spine than femur; increased C telopeptides and alkaline phosphatase were observed, although osteocalcin was normal. Patients with TM presented low bone mineral density and high bone turnover. It’s possible that subjects with increased reabsorbtion, have a marked bone loss and a progressive increased fracture risk.

Item Type:	Article
Uncontrolled Keywords:	Thalassemia major, bone mineral density, bone turnover, osteoporosis
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	23 Apr 2014 16:48
Last Modified:	23 Apr 2014 16:48
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8817

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