Vascular Endothelial Growth Factor-111 (VEGF-111) and tendon healing: preliminary results in a rat model of tendon injury

Kaux, Jean-François and Janssen, Lauriane and Drion, Pierre and Nusgens, Betty and Libertiaux, Vincent and Pascon, Frédéric and Heyeres, Antoine and Hoffmann, Audrey and Lambert, Charles and Le Goff, Caroline and Denoël, Vincent and Defraigne, Jean-Olivier and Rickert, Markus and Crielaard, Jean-Michel and Colige, Alain (2014) Vascular Endothelial Growth Factor-111 (VEGF-111) and tendon healing: preliminary results in a rat model of tendon injury. M.L.T.J. Muscles, Ligaments and Tendons Journal, 4 (1). pp. 24-28. ISSN 2240-4554

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Abstract

Tendon lesions are among the most frequent musculoskeletal pathologies. Vascular endothelial growth factor (VEGF) is known to regulate angiogenesis. VEGF-111, a biologically active and proteolysis-resistant splice variant of this family, was recently identified. This study aimed at evaluating whether VEGF-111 could have a therapeutic interest in tendon pathologies. Surgical section of one Achilles tendon of rats was performed before a local injection of either saline or VEGF-111. After 5, 15 and 30 days, the Achilles tendons of 10 rats of both groups were sampled and submitted to a biomechanical tensile test. The force necessary to induce tendon rupture was greater for tendons of the VEGF-111 group (p<0.05) while the section areas of the tendons were similar. The mechanical stress was similar at 5 and 15 days in the both groups but was improved for the VEGF-111 group at day 30 (p <0.001). No difference was observed in the mRNA expression of collagen III, tenomodulin and MMP-9. In conclusion, we observed that a local injection of VEGF-111 improves the early phases of the healing process of rat tendons after a surgical section. Further confirmatory experimentations are needed to consolidate our results

Item Type:	Article
Uncontrolled Keywords:	Biomechanical, growth factor, healing, tendon, VEGF, VEGF-111
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	10 Nov 2014 16:25
Last Modified:	10 Nov 2014 16:25
URI:	http://eprints.bice.rm.cnr.it/id/eprint/9968

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