Learning about PRP using cell-based models

Beitzel, Knut and McCarthy, Mary Beth and Russell, Ryan P. and Apostolakos, John and Cote, Mark P. and Mazzocca, Augustus D. (2014) Learning about PRP using cell-based models. M.L.T.J. Muscles, Ligaments and Tendons Journal, 4 (1). pp. 38-45. ISSN 2240-4554

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Abstract

Studies using in vitro cell models enable evaluation of the effects of different PRP products under very controlled and standardized conditions. Therefore the results of such studies build the basis for understanding the variable results of clinical studies on the use of PRPs. The main lessons learned through the use of in vitro cell models are that many different PRP products exist and researchers have to report on component variation within each product. These different products may have distinctive effects on the various cells treated in musculoskeletal injuries; therefore, some products might be more beneficial in certain indication than others. In its utilization in cell models, PRP may generate a variety of positive effects on cell proliferation, recovery, and inflammatory response. There might also be a benefit to adding PRP to current pharmacological therapies (e.g. corticosteroids) to prevent their commonly known negative effects on e.g. tendon and cartilage tissue

Item Type:	Article
Uncontrolled Keywords:	Platelet-rich plasma, PRP, tendon, tenocytes, in vitro
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.6 Malattie del sistema urogenitale, malattie del sistema urinario
Depositing User:	Danilo Dezzi
Date Deposited:	10 Nov 2014 16:59
Last Modified:	10 Nov 2014 16:59
URI:	http://eprints.bice.rm.cnr.it/id/eprint/9991

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