The vitamin D receptor: biological and molecular properties

Martineti, Valentina and Carbonell, Silvia and Masi, Laura and Falchetti, Alberto and Brandi, Maria Luisa (2006) The vitamin D receptor: biological and molecular properties. Clinical cases in mineral and bone metabolism, 3 (1). pp. 11-22. ISSN 1971-3266

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Abstract

Vitamin D/Vitamin D Receptor (VDR) endocrine system plays an essential role in regulation of calcium homeostasis and bone metabolism together with other calciotropic hormones. However recent studies evidenced further unexpected roles for this complex system ranging from control of cell proliferation and differentiation to modulation of the immune system. Similarly to other proteins, belonging to the family of nuclear hormone receptors, VDR shows different molecular mechanisms supporting the wide range of its biological actions. Among them the regulation of transcription of vitamin D-dependent genes is the most important one. This paper is a comprehensive review of the biological actions of VDR but for each of them an attempt to give details of the molecular mechanism has been made. Special attention has been paid in evidencing the important role of genomic and proteomic approaches in the study of such a complex system where different signal pathways are involved. The second part of the paper is dedicated to polymorphic variants of VDR gene with special care for functional implications, thus functional studies rather then genetics ones have been reviewed in this section.

Item Type: Article
Uncontrolled Keywords: Vitamin D receptor, functionality, genetics, polymorphisms
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 612 Fisiologia umana > 612.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 24 Jan 2014 14:04
Last Modified: 24 Jan 2014 14:04
URI: http://eprints.bice.rm.cnr.it/id/eprint/4631

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