Use of basal insulin analog detemir in pregnant women with type 1 diabetes: a case-control retrospective study

Imbergamo, Maria P. and Amato, Marco Calogero and Amodeo, Roberta and Magistro, A. and Galluzzo, Aldo and Giordano, Carla (2012) Use of basal insulin analog detemir in pregnant women with type 1 diabetes: a case-control retrospective study. Giornale italiano di ostetricia e ginecologia, 34 (4). pp. 491-498. ISSN 1971-1433

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Abstract

Objective. A poor glycemic control during pregnancy is associated with negative pregnancy outcomes and the frequency of pregnancy complications in women with preexisting type 1 diabetes remains high. Our aim was to evaluate retrospectively (years 2006-2011) the effectiveness and safety of insulin detemir vs NPH insulin in women with type 1 diabetes mellitus (T1DM) during pregnancy. Methods. Sixteen pregnant T1DM women were included in the study. Among them, 8 maintained the previous therapy with detemir and 8 with NPH. All T1DM patients used short-acting analogs (lispro or aspart) in combination with basal insulin once daily. T1DM pregnant women were evaluated for glycemic status and presence of complications. 43 healthy pregnant women were used as control subjects for fetal and neonatal parameters. Results. No statistically significant differences were detected between detemir and NPH-treated pregnant women. No fetal or neonatal parameters were statistically different in relation to the basal insulin treatment. Conclusions. Insulin detemir is well tolerated as NPH with respect to both maternal parameters in pregnant women and perinatal morbidity and mortality. Although our data need to be confirmed by larger prospective studies, they suggest that insulin detemir represents a valuable option in the management of pregnant women with diabetes.

Item Type:	Article
Uncontrolled Keywords:	Diabetes type 1, detemir, pregnancy, neonatal outcome, maternal outcome
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 618 Altri rami della medicina; Ginecologia e ostetricia, Pediatria, Geriatria
Depositing User:	Matteo Viola
Date Deposited:	28 Aug 2013 16:45
Last Modified:	28 Aug 2013 16:45
URI:	http://eprints.bice.rm.cnr.it/id/eprint/6613

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