Bioactive factors for tissue regeneration: state of the art

Ohba, Shinsuke and Hojo, Hironori and Chung, Ung-il (2012) Bioactive factors for tissue regeneration: state of the art. M.L.T.J. Muscles, Ligaments and Tendons Journal, 2 (3). pp. 193-203. ISSN 2240-4554

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Abstract

There are three components for the creation of new tissues: cell sources, scaffolds, and bioactive factors. Unlike conventional medical strategies, regenerative medicine requires not only analytical approaches but also integrative ones. Basic research has identified a number of bioactive factors that are necessary, but not sufficient, for organogenesis. In skeletal development, these factors include bone morphogenetic proteins (BMPs), transforming growth factor b TGF-b, Wnts, hedgehogs (Hh), fibroblast growth factors (FGFs), insulin-like growth factors (IGFs), SRY boxcontaining gene (Sox) 9, Sp7, and runt-related transcription factors (Runx). Clinical and preclinical studies have been extensively performed to apply the knowledge to bone and cartilage regeneration. Given the large number of findings obtained so far, it would be a good time for a multi-disciplinary, collaborative effort to optimize these known factors and develop appropriate drug delivery systems for delivering them

Item Type:	Article
Uncontrolled Keywords:	Bone regeneration, cartilage regeneration, chondrocyte
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	16 Apr 2014 16:23
Last Modified:	16 Apr 2014 16:23
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8142

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